Ohba N, Nakao K, Isashiki Y, Osame M, Sonoda S, Yashiki S, Yamaguchi K, Tajima K
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
Jpn J Ophthalmol. 1994;38(2):162-7.
To elucidate the epidemiology of human T-lymphotropic virus type I (HTLV-I) associated uveitis (HAU), a multicenter case-control study was carried out by the collaboration of university hospitals throughout Kyushu and Okinawa in southwestern Japan where HTLV-I is endemic; two institutions in the non-endemic metropolitan areas of Tokyo and Yokohama also participated. A total of 426 cases of endogenous uveitis were registered during the five-month period between September 1992 and January 1993; the etiology and clinical entity of about half of the cases were definable, and for the remaining half were unknown. Assessment of antibodies to HTLV-I revealed that the group of entity-undefined uveitis cases showed a significantly high seroprevalence when compared with age- and sex-matched controls. Estimate of the risk of HTLV-I provided supportive evidence for its etiologic contribution to a considerable proportion of hitherto undefined isolated uveitis cases. The prevalence of HAU thus defined was found to correspond to the seroprevalence in the relevant areas. Occasional cases were found among residents in the nonendemic metropolitan areas who had moved from the endemic areas.
为阐明人类嗜T淋巴细胞病毒I型（HTLV-I）相关葡萄膜炎（HAU）的流行病学情况，日本西南部九州和冲绳地区（HTLV-I流行地区）的大学医院合作开展了一项多中心病例对照研究；东京和横滨非流行大都市地区的两家机构也参与其中。在1992年9月至1993年1月的五个月期间，共登记了426例内因性葡萄膜炎病例；约一半病例的病因和临床类型可明确，其余一半病例不明。对HTLV-I抗体的评估显示，与年龄和性别匹配的对照组相比，病因不明的葡萄膜炎病例组血清阳性率显著较高。HTLV-I风险评估为其在相当一部分迄今病因不明的孤立性葡萄膜炎病例中的病因学作用提供了支持性证据。如此定义的HAU患病率与相关地区的血清阳性率相符。在从流行地区迁入非流行大都市地区的居民中偶尔也发现了病例。
