Nakao K, Matsumoto M, Ohba N
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
Br J Ophthalmol. 1991 Feb;75(2):76-8. doi: 10.1136/bjo.75.2.76.
Human T-lymphotropic virus type 1 (HTLV-I) has been shown to spread worldwide and to be responsible for distinct systemic diseases, namely adult T-cell leukaemia and HTLV-I-associated myelopathy. Immune-mediated, inflammatory lesions in the lungs, joints, and lacrimal glands (Sjögren's syndrome) are also suggested to be associated with the retrovirus. We studied seroprevalence of antibodies to HTLV-I in patients with various ocular disorders who are residents of south-west Japan, one of the endemic areas of HTLV-I. Of 310 patients with ocular disease 72 (23.2%) were seropositive. This seroprevalence did not differ significantly from that of the general population of the area. As regards individual ocular diseases, aetiologically undefined nonspecific uveitis showed a significantly high seropositivity for HTLV-I. Of 44 patients 18 (40.9%) were seropositive. Their clinical features were acute or subacute, transient and sometimes recurrent, and granulomatous changes in the anterior uvea. Patients with isolated cotton-wool spot of the retina, non-familial retinitis pigmentosa, or keratoconjunctivitis sicca did not show any significantly high prevalence of HTLV-I infection.
人类嗜T淋巴细胞病毒1型（HTLV-I）已被证明在全球范围内传播，并导致不同的全身性疾病，即成人T细胞白血病和HTLV-I相关脊髓病。肺部、关节和泪腺的免疫介导性炎症病变（干燥综合征）也被认为与这种逆转录病毒有关。我们研究了日本西南部（HTLV-I的流行地区之一）各种眼部疾病患者中HTLV-I抗体的血清流行率。在310名眼病患者中，72名（23.2%）血清呈阳性。该血清流行率与该地区普通人群的血清流行率无显著差异。就个别眼部疾病而言，病因不明的非特异性葡萄膜炎对HTLV-I的血清阳性率显著较高。在44名患者中，18名（40.9%）血清呈阳性。其临床特征为急性或亚急性、短暂性且有时复发，前葡萄膜有肉芽肿性改变。孤立性视网膜棉絮斑、非家族性视网膜色素变性或干燥性角结膜炎患者未显示出HTLV-I感染的任何显著高流行率。
