Cossu A, Massarelli G, Manetto V, Viale G, Tanda F, Bosincu L, Iuzzolino P, Cossu S, Padovani R, Eusebi V
Istituto di Anatomia ed Istologia Patologica, Università di Sassari, Italy.
Virchows Arch A Pathol Anat Histopathol. 1993;422(1):81-5. doi: 10.1007/BF01605137.
Three cases of rhabdoid tumour of the central nervous system arising in a supratentorial location are reported. The patients were 18, 14, and 7 years old. All three tumours showed a common morphology. The neoplastic cells were usually globoid with round nuclei and prominent nucleoli and large acidophilic, cytoplasmic inclusions were present in many of them. These inclusions showed strong immunoreactivity for vimentin, weak immunoreactivity for epithelial membrane antigen and focal immunoreactivity for cytokeratins. Ultrastructurally they were made up of whorls of intermediate filaments, 8-10 nm in thickness. Rhabdoid tumours of the central nervous system, whatever the cell of origin, appear to be an independent entity with identifiable histology and aggressive behaviour.
报告了3例起源于幕上部位的中枢神经系统横纹肌样瘤。患者年龄分别为18岁、14岁和7岁。所有3个肿瘤均表现出共同的形态学特征。肿瘤细胞通常呈球状，核圆形，核仁突出，许多细胞内可见大的嗜酸性胞质包涵体。这些包涵体对波形蛋白呈强免疫反应性，对上皮膜抗原呈弱免疫反应性，对角蛋白呈局灶性免疫反应性。超微结构上，它们由厚度为8 - 10 nm的中间丝束组成。中枢神经系统横纹肌样瘤，无论起源细胞如何，似乎都是一个具有可识别组织学和侵袭性行为的独立实体。
