Jackson M A, Stack H F, Waters M D
Environmental Health Research and Testing, Inc., Research Triangle Park, NC 27709.
Mutat Res. 1993 Mar;296(3):241-77. doi: 10.1016/0165-1110(93)90014-e.
This report examines a group of putative nongenotoxic carcinogens that have been cited in the published literature. Using short-term test data from the U.S. Environmental Protection Agency/International Agency for Research on Cancer genetic activity profile (EPA/IARC GAP) database we have classified these agents on the basis of their mutagenicity emphasizing three genetic endpoints: gene mutation, chromosomal aberration and aneuploidy. On the basis of results of short-term tests for these effects, we have defined criteria for evidence of mutagenicity (and nonmutagenicity) and have applied these criteria in classifying the group of putative nongenotoxic carcinogens. The results from this evaluation based on the EPA/IARC GAP database are presented along with a summary of the short-term test data for each chemical and the relevant carcinogenicity results from the NTP, Gene-Tox and IARC databases. The data clearly demonstrate that many of the putative nongenotoxic carcinogens that have been adequately tested in short-term bioassays induce gene or chromosomal mutations or aneuploidy.
本报告研究了一批已在公开文献中被引用的假定非遗传毒性致癌物。利用美国环境保护局/国际癌症研究机构遗传活性概况（EPA/IARC GAP）数据库中的短期测试数据，我们根据这些物质的致突变性对其进行了分类，重点关注三个遗传终点：基因突变、染色体畸变和非整倍体。基于这些效应的短期测试结果，我们定义了致突变性（和非致突变性）证据的标准，并将这些标准应用于对假定非遗传毒性致癌物组的分类。基于EPA/IARC GAP数据库的评估结果与每种化学物质的短期测试数据总结以及来自NTP、基因毒性和IARC数据库的相关致癌性结果一同呈现。数据清楚地表明，许多在短期生物测定中经过充分测试的假定非遗传毒性致癌物会诱导基因或染色体突变或非整倍体。
