来自对尘螨过敏患者的表达Fcε受体细胞上Der p I衍生肽的生物学活性比较分析。
Comparative analysis of biological activities of Der p I-derived peptides on Fc epsilon receptor-bearing cells from Dermatophagoides pteronyssinus-sensitive patients.
作者信息
Jeannin P, Pestel J, Bossus M, Lassalle P, Tartar A, Tonnel A B
机构信息
Pathologie Immuno-Allergique Respiratoire et Cellules Inflammatoires, INSERM CJF 90-06, Institut Pasteur, Lille, France.
出版信息
Clin Exp Immunol. 1993 Apr;92(1):133-8. doi: 10.1111/j.1365-2249.1993.tb05959.x.
The ability of four uncoupled synthetic peptides (p52-71, p117-133, p176-187, p188-199) derived from Der p I, a major allergen from the house dust mite Dermatophagoides pteronyssinus (Dpt) to stimulate Fc epsilon R+ cells from Dpt-sensitive patients was comparatively analysed. Each free peptide may specifically stimulate basophils (Fc epsilon RI+ cells) and platelets (Fc epsilon RII+ cells) from patients with significant levels of anti-Der p I IgE antibodies; p52-71 and p117-133 appear the best cell stimulation inducers. Both concentration-dependent biological activities of Der p I-peptide on Fc epsilon R+ cells are enhanced by coupling peptide to a carrier (as human serum albumin). Interestingly each Der p I-sensitive patient tested presents an individual pattern of response to peptide. Thus, from our results it appears that different Der p I sequences could be involved in the immune response to Der p I.
对源自屋尘螨（粉尘螨）主要变应原Der p I的四种非偶联合成肽（p52 - 71、p117 - 133、p176 - 187、p188 - 199）刺激粉尘螨敏感患者的FcεR⁺细胞的能力进行了比较分析。每种游离肽可特异性刺激抗Der p I IgE抗体水平显著的患者的嗜碱性粒细胞（FcεRI⁺细胞）和血小板（FcεRII⁺细胞）；p52 - 71和p117 - 133似乎是最佳的细胞刺激诱导剂。通过将肽与载体（如人血清白蛋白）偶联，Der p I - 肽对FcεR⁺细胞的两种浓度依赖性生物学活性均得到增强。有趣的是，每个接受测试的Der p I敏感患者对肽的反应呈现出个体模式。因此，从我们的结果来看，不同的Der p I序列可能参与了对Der p I的免疫反应。
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