Marcellin P, Martinot-Peignoux M, Elias A, Branger M, Courtois F, Level R, Erlinger S, Benhamou J P
Service d'Hépatologie, INSERM U24, Hôpital Beaujon, Clichy, France.
J Infect Dis. 1994 Aug;170(2):433-5. doi: 10.1093/infdis/170.2.433.
Positivity of recombinant immunoblot assay (RIBA) for detection of antibodies to hepatitis C virus (anti-HCV) is usually associated with HCV viremia. The significance of an indeterminate RIBA result, defined by reactivity to only one HCV antigen, is unclear. Whether anti-human immunodeficiency virus (HIV)-negative or -positive subjects with an indeterminate RIBA have HCV viremia detectable by polymerase chain reaction was investigated. An indeterminate RIBA was found in 48 (15%) of 318 anti-HIV-negative and 38 (23%) of 167 anti-HIV-positive subjects (P < .05). Clinical stage was IV-C-1 or IV-C-2 in 82% of those anti-HIV-positive. HCV viremia was found more frequently in anti-HIV-positive (89%) than in anti-HIV-negative subjects (50%) with an indeterminate RIBA (P < .05). These results suggest an impaired anti-HCV response associated with HIV infection.
重组免疫印迹法（RIBA）检测丙型肝炎病毒抗体（抗-HCV）呈阳性通常与丙型肝炎病毒血症相关。仅对一种丙型肝炎病毒抗原呈反应性所定义的不确定RIBA结果的意义尚不清楚。研究了抗人类免疫缺陷病毒（HIV）阴性或阳性且RIBA结果不确定的受试者是否存在可通过聚合酶链反应检测到的丙型肝炎病毒血症。在318名抗HIV阴性受试者中有48名（15%）以及167名抗HIV阳性受试者中有38名（23%）出现不确定的RIBA结果（P <.05）。抗HIV阳性受试者中82%的临床分期为IV-C-1或IV-C-2。在RIBA结果不确定的受试者中，抗HIV阳性者（89%）比抗HIV阴性者（50%）更频繁地检测到丙型肝炎病毒血症（P <.05）。这些结果提示与HIV感染相关的抗HCV反应受损。
