Blennow K, Wallin A, Gottfries C G, Karlsson I, Månsson J E, Skoog I, Wikkelsö C, Svennerholm L
Department of Psychiatry, University of Göteborg, Sweden.
Eur Neuropsychopharmacol. 1993 Mar;3(1):55-61. doi: 10.1016/0924-977x(93)90295-w.
Concentrations of the monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxyphenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 114 healthy individuals, 18-88 years of age, without histories, symptoms or signs of central nervous system dysfunction. The mean values (+/- SD) were 253 +/- 109 nmol/l for HVA, 125 +/- 54 nmol/l for 5-HIAA, 47 +/- 10 nmol/l for HMPG, and 2.10 +/- 0.52 for the HVA/5-HIAA ratio. Analyses of confounding factors revealed that all metabolites correlated negatively with body height, the values being lower in taller than in shorter individuals. This is probably attributable to a larger surface area for monoamine metabolite transport from the subarachnoid space in taller than in shorter individuals. These correlations make statistical adjustment for body height important in analyses of monoamine metabolite levels. Without considering body height, all monoamine metabolites showed a positive correlation with age, and higher levels of HVA and 5-HIAA were found in women than men. After statistical adjustment for the influence of body height, no differences in CSF monoamine metabolites levels were found between the sexes, and only 5-HIAA showed a positive correlation with age. There were no significant seasonal variations for any of the monoamine metabolites.
在114名年龄在18至88岁之间、无中枢神经系统功能障碍病史、症状或体征的健康个体的腰椎脑脊液（CSF）中，测定了单胺代谢产物高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和4-羟基-3-甲氧基苯乙二醇（HMPG）的浓度。HVA的平均值（±标准差）为253±109 nmol/l，5-HIAA为125±54 nmol/l，HMPG为47±10 nmol/l，HVA/5-HIAA比值为2.10±0.52。对混杂因素的分析表明，所有代谢产物与身高均呈负相关，身高较高者的值低于身高较矮者。这可能是由于身高较高者蛛网膜下腔单胺代谢产物转运的表面积大于身高较矮者。这些相关性使得在分析单胺代谢产物水平时对身高进行统计调整很重要。在不考虑身高的情况下，所有单胺代谢产物与年龄均呈正相关，且女性的HVA和5-HIAA水平高于男性。在对身高的影响进行统计调整后，两性之间脑脊液单胺代谢产物水平无差异，只有5-HIAA与年龄呈正相关。任何单胺代谢产物均无明显的季节性变化。
