Wallin A, Blennow K, Edman A, Månsson J E
Göteborg University, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Sweden.
Int Psychogeriatr. 1996 Fall;8(3):425-36. doi: 10.1017/s1041610296002785.
The levels of the monoamine metabolites 5-hydroxy-indoleacetic acid (5-HIAA), homovanillic acid (HVA), and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 56 patients with vascular dementia (VAD) and 57 healthy controls. Despite CSF sampling under standardized conditions, the variability in values was wide among both patients and controls. This suggests that yet unknown factors affect the lumbar CSF concentrations of monoamine metabolites. The VAD group showed significantly lower mean concentrations of 5-HIAA (p < .001) and HVA (p < .001) than the control group. These low concentrations appear to be no disease-specific phenomenon, but may be attributable to subcortical white-matter changes or a decreased production of monoamines, which are dependent on oxygen for their synthesis.
在56例血管性痴呆（VAD）患者和57例健康对照者的腰椎脑脊液（CSF）中测定了单胺代谢产物5-羟吲哚乙酸（5-HIAA）、高香草酸（HVA）和4-羟基-3-甲氧基苯乙二醇（HMPG）的水平。尽管在标准化条件下采集脑脊液，但患者和对照者的值变异性都很大。这表明尚不清楚的因素会影响腰椎脑脊液中单胺代谢产物的浓度。VAD组的5-HIAA（p <.001）和HVA（p <.001）平均浓度显著低于对照组。这些低浓度似乎不是疾病特异性现象，而可能归因于皮质下白质变化或单胺生成减少，单胺的合成依赖于氧气。
