Tanoh T, Shimatsu A, Ishikawa Y, Ihara C, Yanaihara N, Imura H
Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.
J Neuroendocrinol. 1993 Apr;5(2):183-7. doi: 10.1111/j.1365-2826.1993.tb00379.x.
Intracerebroventricular administration of galanin (GAL) potently evoked growth hormone (GH) secretion in conscious male rats. Pretreatments with neostigmine and cysteamine blunted the GAL-induced GH secretion. Pretreatment of animals with a specific anti-somatostatin serum significantly inhibited the GAL-induced GH secretion. On the contrary, GH-releasing hormone-induced GH secretion was significantly enhanced with cysteamine and anti-somatostatin serum. These results suggest that somatostatin is involved in GAL-induced GH secretion in rats.
