Grootveld M, Claxson A W, Chander C L, Haycock P, Blake D R, Hawkes G E
Inflammation Research Group, London Hospital Medical College, UK.
FEBS Lett. 1993 May 17;322(3):266-76. doi: 10.1016/0014-5793(93)81584-m.
An intense broad resonance at 2.14 ppm present in high field (400, 500 and 600 MHz) Hahn spin-echo 1H-NMR spectra of rat blood plasma, but absent from those of human blood plasma is attributable to the presence of terminal O-acetylsialate sugars in the molecularly mobile carbohydrate side-chains of 'acute-phase' glycoproteins (predominantly alpha 1-acid glycoprotein). The presence of such alternative acetylsugars in the carbohydrate side-chains of rat plasma glycoproteins are of much physiological and experimental significance in view of the regular use of these animals in model systems of human inflammatory conditions.
