Fowler F J, Barry M J
Center for Survey Research, University of Massachusetts, Boston 02125-3393.
Eur Urol. 1993;24 Suppl 1:24-7. doi: 10.1159/000474370.
546 patients enrolled in a prospective study of patient treatment choices for benign prostatic hyperplasia (BPH) completed a self-administered questionnaire that included a symptom index, two general measures of quality of life, and a condition-specific measure of the impact of BPH symptoms on patient quality of life. As expected, differences in symptoms of BPH were significantly associated with general measures of quality of life and the condition-specific impact score. However, the condition-specific impact score was more sensitive to differences in symptoms than the general measures. Hence, such measures are likely to be more responsive to treatment effects, may provide more power for statistical analysis, and hence should be considered along with general quality of life measures for use in treatment outcome studies.
546名参与良性前列腺增生（BPH）患者治疗选择前瞻性研究的患者完成了一份自我管理问卷，该问卷包括一个症状指数、两个生活质量综合指标以及一个针对BPH症状对患者生活质量影响的特定疾病指标。正如预期的那样，BPH症状差异与生活质量综合指标以及特定疾病影响评分显著相关。然而，特定疾病影响评分对症状差异比综合指标更敏感。因此，这类指标可能对治疗效果更具反应性，可能为统计分析提供更大效力，故而在治疗结果研究中应与生活质量综合指标一同考虑使用。
