Budde J, Tronnier H, Rahlfs V W, Frei-Kleiner S
Hautärztliche Praxis, Marl.
Hautarzt. 1993 Jun;44(6):380-4.
A controlled randomized double-blind study was carried out in 72 female patients to compare tolerance and efficacy of two therapeutic agents containing vitamins of the B-group and L-cystine in different compositions versus a placebo in diffuse effluvia and hair structure lesions. Hair swelling as a criterion of hair quality and frontal and parietal anagen rates in trichograms as criteria of hair growth were determined before and after 4 months of therapy. Treatment with active medication 1 was statistically significantly superior to treatment with the placebo according to these criteria. Treatment with active medication 2 was superior to treatment with the placebo but inferior to treatment with active medication 1. The overall evaluation of efficacy by investigator and patient was in good agreement with these results. The additional active ingredients contained in active medication 1 but not contained in active medication 2 contribute to the efficacy of the medication. They cannot be compensated by the higher amounts of L-cystine contained in active medication 2. Given their good tolerance, no adverse effects were observed with the two active medications.
对72名女性患者进行了一项对照随机双盲研究，以比较两种不同成分的含B族维生素和L-胱氨酸的治疗药物与安慰剂在弥漫性脱发和头发结构损伤方面的耐受性和疗效。在治疗4个月前后，分别测定头发肿胀情况（作为头发质量的标准）以及毛发镜检查中额部和顶部生长期毛发率（作为头发生长的标准）。根据这些标准，活性药物1治疗在统计学上显著优于安慰剂治疗。活性药物2治疗优于安慰剂治疗，但劣于活性药物1治疗。研究者和患者对疗效的总体评估与这些结果高度一致。活性药物1中含有的但活性药物2中未含有的额外活性成分有助于药物疗效。活性药物2中较高含量的L-胱氨酸无法弥补这一点。鉴于两种活性药物耐受性良好，未观察到不良反应。
