Karlin K D
Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218.
Science. 1993 Aug 6;261(5122):701-8. doi: 10.1126/science.7688141.
Metalloenzymes effect a variety of important chemical transformations, often involving small molecule substrates or products such as molecular oxygen, hydrogen, nitrogen, and water. A diverse array of ions or metal clusters is observed at the active-site cores, but living systems use basic recurring structures that have been modified or tuned for specific purposes. Inorganic chemists are actively involved in the elucidation of the structure, spectroscopy, and mechanism of action of these biological catalysts, in part through a synthetic modeling approach involving biomimetic studies.
金属酶催化各种重要的化学转化反应，这些反应通常涉及小分子底物或产物，如分子氧、氢、氮和水。在活性位点核心观察到各种各样的离子或金属簇，但生命系统使用的是经过修饰或调整以用于特定目的的基本重复结构。无机化学家积极参与阐明这些生物催化剂的结构、光谱和作用机制，部分是通过涉及仿生研究的合成建模方法来实现的。
