Hviid L, Theander T G, Elhassan I M, Jensen J B
Department of Infectious Diseases, University Hospital, Copenhagen, Denmark.
Immunol Lett. 1993 Apr;36(1):51-8. doi: 10.1016/0165-2478(93)90068-d.
Acute P. falciparum malaria is associated with a loss of antigen-responsiveness of peripheral T cells, depletion of T cells characterized by high surface expression of the adhesion molecule LFA-1, and increased plasma levels of the T-cell activation marker soluble IL-2 receptor (sIL-2R). In the present study we show that clinical episodes of P. falciparum malaria produced an increase in plasma levels of soluble ICAM-1 (sICAM-1) and ELAM-1 (sELAM-1). The increase was transient and subsided slowly (sICAM-1) or rapidly (sELAM-1) following drug cure. The increases in plasma sICAM-1 and sELAM-1 were significantly correlated, and were furthermore associated with a concomitant increase in plasma levels of sIL-2R. Finally, plasma levels of sICAM-1, but not sELAM-1, were inversely correlated to the fraction of peripheral T cells having high surface expression of LFA-1, the receptor for T-cell adhesion to ICAM-1. Taken together, these observations suggest that acute P. falciparum malaria is characterized by a state of endothelial inflammation associated with the adherence of activated T cells.
恶性疟原虫急性疟疾与外周血T细胞抗原反应性丧失、以黏附分子LFA-1高表面表达为特征的T细胞耗竭以及T细胞活化标志物可溶性白细胞介素-2受体（sIL-2R）血浆水平升高有关。在本研究中，我们发现恶性疟原虫疟疾的临床发作导致可溶性细胞间黏附分子-1（sICAM-1）和内皮白细胞黏附分子-1（sELAM-1）的血浆水平升高。这种升高是短暂的，药物治愈后缓慢（sICAM-1）或迅速（sELAM-1）消退。血浆sICAM-1和sELAM-1的升高显著相关，并且还与sIL-2R血浆水平的同时升高有关。最后，sICAM-1而非sELAM-1的血浆水平与具有高表面LFA-1表达的外周血T细胞比例呈负相关，LFA-1是T细胞黏附于ICAM-1的受体。综上所述，这些观察结果表明，恶性疟原虫急性疟疾的特征是与活化T细胞黏附相关的内皮炎症状态。
