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无机硅(Si)对垂体-甲状腺轴的影响。

The influence of inorganic silicon (Si) on pituitary-thyroid axis.

作者信息

Najda J, Gmiński J, Drózdz M, Zych F

机构信息

Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.

出版信息

Biol Trace Elem Res. 1993 May-Jun;37(2-3):101-6. doi: 10.1007/BF02783785.

DOI:10.1007/BF02783785
PMID:7688523
Abstract

The influence of silicon-treatment on the levels of TSH and thyroid hormones was studied in rats. Concentrations of thyrotropin (TSH), triiodothyronine (T3), and thyroxine (T4) were estimated in sera of rats receiving per os a soluble silicon compound--sodium metasilicate nonahydrate (Na2SiO3.9H2O), dissolved in the animals' drinking water. An increase in the TSH level in the tested group was observed, without statistically significant differences in T3 and T4 concentrations between the two groups of animals. The results provide evidence for the influence of silicon on the endocrine balance. They could also prove that this chemical element is capable of modifying the rate of some hormones' synthesis.

摘要

研究了硅处理对大鼠促甲状腺激素(TSH)和甲状腺激素水平的影响。通过经口给大鼠喂食溶解于动物饮用水中的可溶性硅化合物——九水偏硅酸钠(Na2SiO3·9H2O),测定大鼠血清中促甲状腺激素(TSH)、三碘甲状腺原氨酸(T3)和甲状腺素(T4)的浓度。观察到试验组TSH水平升高,两组动物的T3和T4浓度无统计学显著差异。这些结果为硅对内分泌平衡的影响提供了证据。它们还可以证明这种化学元素能够改变某些激素的合成速率。

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1
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2
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本文引用的文献

1
The nutritional essentiality of silicon.硅的营养必需性。
Nutr Rev. 1982 Jul;40(7):193-8. doi: 10.1111/j.1753-4887.1982.tb05307.x.
2
Silicon metabolism. II. Renal handling in chronic renal failure patients.硅代谢。II. 慢性肾衰竭患者的肾脏处理
Nephron. 1986;44(1):36-9. doi: 10.1159/000183909.
3
Silicon metabolism. I. Some aspects of renal silicon handling in normal man.硅代谢。I. 正常人体内肾脏对硅处理的某些方面。
Nephron. 1986;43(1):5-9. doi: 10.1159/000183709.
4
Ultrastructural-immunocytochemical localization of endogenous calcitonin in osteoblasts of silicon-treated rats.硅处理大鼠成骨细胞内源性降钙素的超微结构免疫细胞化学定位
Ann Endocrinol (Paris). 1987;48(6):481-3.