Høiby N, Pedersen S S, Jensen T, Valerius N H, Koch C
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Drugs. 1993;45 Suppl 3:98-101. doi: 10.2165/00003495-199300453-00017.
Cystic fibrosis patients suffer from recurrent and chronic lung infections mainly caused by Staphylococcus aureus, Haemophilus influenzae and Pseudomonas aeruginosa. The fluoroquinolones, notably ciprofloxacin and ofloxacin, represent an important addition to the therapy of P. aeruginosa infections. They offer the possibility of effective oral treatment for early colonisation as well as chronic infections, even in children. They are associated with only few and mild adverse effects. Development of resistance represents an increasing problem.
囊性纤维化患者会反复遭受慢性肺部感染，主要由金黄色葡萄球菌、流感嗜血杆菌和铜绿假单胞菌引起。氟喹诺酮类药物，尤其是环丙沙星和氧氟沙星，是治疗铜绿假单胞菌感染的重要补充药物。它们为早期定植以及慢性感染提供了有效的口服治疗可能性，甚至对儿童也适用。它们仅伴有很少且轻微的不良反应。耐药性的产生是一个日益严重的问题。
