Vlad M, Bordas E, Tomus R, Sava D, Farkas E, Uza G
Institute of Public Health and Medical Research, Cluj-Napoca, Romania.
Biol Trace Elem Res. 1993 Jul;38(1):47-54. doi: 10.1007/BF02783981.
Serum copper concentration increases significantly (p < 0.01) in rats with experimental atherosclerosis compared to a control group. The serum zinc, the zinc, and copper concentration in abdominal aorta and in liver decreases significantly (p < 0.05) compared to the control group. Administration of copper sulfate for 100 d in these animals induces a significant increase of serum copper (p < 0.01), decrease of serum cholesterol (p < 0.05) and increase of liver copper concentration as compared with the group fed only a high cholesterol diet. In the aorta of these animals the copper concentration increases and edema and lipid infiltration are considerably less than in the group of animals fed only a high lipid diet.
与对照组相比，实验性动脉粥样硬化大鼠的血清铜浓度显著升高（p < 0.01）。与对照组相比，腹主动脉和肝脏中的血清锌、锌和铜浓度显著降低（p < 0.05）。在这些动物中给予硫酸铜100天，与仅喂食高胆固醇饮食的组相比，血清铜显著增加（p < 0.01），血清胆固醇降低（p < 0.05），肝脏铜浓度增加。在这些动物的主动脉中，铜浓度增加，水肿和脂质浸润明显少于仅喂食高脂饮食的动物组。
