Morgan E J, Hall D R
Thorax. 1976 Feb;31(1):80-6. doi: 10.1136/thx.31.1.80.
Twenty subjects with symptoms of hay fever were studied to see whether abnormalities could be detected in the function of small airways. The investigations included dynamic compliance at varying respiratory frequencies, closing capacity, residual volume, transfer factor, and maximal expiratory flow-volume curves. The tests were repeated in the winter when symptoms had resolved. Frequency dependence of compliance was found in eight subjects with symptoms (40%), closing capacities being abnormal in only two instances. Conventional pulmonary function tests, including expiratory flow rates at mid vital capacity, were within the predicted range of all subjects. When tests were repeated in the winter, frequency dependence of compliance was no longer present in subjects whose symptoms had resolved. The study suggests that reversible small airway abnormalities are present in a significant proportion of subjects with symptoms of hay fever and that such abnormalities are best detected by the measurement of dynamic compliance at varying respiratory frequencies.
对20名有花粉热症状的受试者进行了研究，以观察小气道功能是否能检测到异常。研究包括不同呼吸频率下的动态顺应性、闭合容量、残气量、转移因子和最大呼气流量-容积曲线。在冬季症状缓解时重复进行这些测试。在8名有症状的受试者（40%）中发现了顺应性的频率依赖性，仅在两例中闭合容量异常。包括肺活量中期呼气流量率在内的传统肺功能测试在所有受试者的预测范围内。当在冬季重复测试时，症状已缓解的受试者中不再存在顺应性的频率依赖性。该研究表明，相当一部分有花粉热症状的受试者存在可逆性小气道异常，并且通过测量不同呼吸频率下的动态顺应性能最好地检测到此类异常。
