Bodfish J W, Powell S B, Golden R N, Lewis M H
Western Carolina Center, USA.
Am J Ment Retard. 1995 Jan;99(4):335-44.
Direct observation of blink rate was used as a noninvasive, in vivo estimate of dopamine function in adults with mental retardation and repetitive behavior disorders. Blink rate as measured in groups of stereotypy, compulsion, and control subjects was highly stable. Subjects with stereotypies had significantly lower blink rates than did control subjects. Although blink rates for compulsive subjects were not significantly different from those of control subjects, a subgroup of compulsive subjects with comorbid stereotypic behaviors displayed significantly lower blink rates. Significant inverse correlations were found for blink rate and severity of repetitive behavior disorder and for blink rate and ratings of motor slowness. These findings support the hypothesis that stereotyped behavior among adults with mental retardation is mediated by hypodopaminergic function.
直接观察眨眼频率被用作一种非侵入性的、在体评估患有智力障碍和重复行为障碍的成年人多巴胺功能的方法。在刻板行为组、强迫行为组和对照组中测量的眨眼频率高度稳定。患有刻板行为的受试者的眨眼频率显著低于对照组受试者。虽然强迫行为受试者的眨眼频率与对照组受试者的没有显著差异，但一组伴有共病刻板行为的强迫行为受试者的眨眼频率显著较低。眨眼频率与重复行为障碍的严重程度以及眨眼频率与运动迟缓评分之间存在显著的负相关。这些发现支持了这样一种假设，即智力障碍成年人中的刻板行为是由多巴胺能功能减退介导的。
