Colzato Lorenza Serena, van den Wildenberg Wery P M, van Wouwe Nelleke C, Pannebakker Merel M, Hommel Bernhard
Cognitive Psychology Unit, Department of Psychology, Leiden Institute for Brain and Cognition, Leiden University, Postbus 9555, 2300 RB, Leiden, The Netherlands.
Exp Brain Res. 2009 Jul;196(3):467-74. doi: 10.1007/s00221-009-1862-x. Epub 2009 May 31.
The inhibitory control of actions has been claimed to rely on dopaminergic pathways. Given that this hypothesis is mainly based on patient and drug studies, some authors have questioned its validity and suggested that beneficial effects of dopaminergic stimulants on response inhibition may be limited to cases of suboptimal inhibitory functioning. We present evidence that, in carefully selected healthy adults, spontaneous eyeblink rate, a marker of central dopaminergic functioning, reliably predicts the efficiency in inhibiting unwanted action tendencies in a stop-signal task. These findings support the assumption of a modulatory role for dopamine in inhibitory action control.
动作的抑制控制被认为依赖于多巴胺能通路。鉴于这一假设主要基于对患者和药物的研究，一些作者对其有效性提出了质疑，并认为多巴胺能兴奋剂对反应抑制的有益作用可能仅限于抑制功能欠佳的情况。我们提供的证据表明，在精心挑选的健康成年人中，作为中枢多巴胺能功能标志物的自发眨眼率，能够可靠地预测在停止信号任务中抑制不必要动作倾向的效率。这些发现支持了多巴胺在抑制性动作控制中具有调节作用的假设。
