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PREDISAFE的评估，一种用于预测化妆品原料和配方眼部刺激性的细胞试剂盒。

Evaluation of PREDISAFE, a cell kit for predicting eye irritancy of cosmetic raw materials and formulations.

作者信息

Guyomard C, Bouffechoux J, Bourniche J, Chesné C

机构信息

BIOPREDIC, Rennes, France.

出版信息

Cell Biol Toxicol. 1994 Dec;10(5-6):375-9. doi: 10.1007/BF00755785.

DOI:10.1007/BF00755785
PMID:7697499
Abstract

A cell kit named PREDISAFE based on the use of confluent rabbit fibroblastic cells has been designed to predict eye irritancy of cosmetic raw materials and formulations. The kit can be stored for a few days and/or shipped at room temperature. Cytotoxicity was estimated after 1 min or 15 min contact with test compounds using the neutral red release assay. For the 84 products tested, IC50 values gave intervals similar to classes defined from the Draize test, i.e., mild, moderate, severe and extreme irritancy.

摘要

一种名为PREDISAFE的细胞试剂盒，基于汇合的兔成纤维细胞的使用而设计，用于预测化妆品原料和配方的眼刺激性。该试剂盒可在室温下储存数天和/或运输。使用中性红释放试验，在与测试化合物接触1分钟或15分钟后评估细胞毒性。对于所测试的84种产品，半数抑制浓度（IC50）值给出的区间与从兔眼刺激试验定义的类别相似，即轻度、中度、重度和极重度刺激。

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本文引用的文献

1
Neutral red release from pre-loaded cells as an in vitro approach to testing for eye irritancy potential.作为一种体外测试眼刺激潜能的方法，预加载细胞中中性红的释放。
Toxicol In Vitro. 1990;4(4-5):264-6. doi: 10.1016/0887-2333(90)90060-7.
2
Evaluation of seven in vitro alternatives for ocular safety testing.七种用于眼部安全性测试的体外替代方法的评估。
Fundam Appl Toxicol. 1991 Jul;17(1):136-49. doi: 10.1016/0272-0590(91)90246-z.

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