Frisoni M, Corazza G R, Lafiandra D, De Ambrogio E, Filipponi C, Bonvicini F, Borasio E, Porceddu E, Gasbarrini G
Università di Bologna, Italy.
Gut. 1995 Mar;36(3):375-8. doi: 10.1136/gut.36.3.375.
The toxicity of two varieties of bread wheat, one poor in alpha and beta gliadins and the other poor in alpha, beta, gamma, and omega gliadins, has been tested. The peptic-tryptic digest of these wheats was assessed using coeliac mucosa in an in vitro organ culture system. A significantly lower toxicity was found in respect of bread wheat containing all gliadin fractions. These results suggest new opportunities for the treatment of coeliac disease.
对两种面包小麦品种的毒性进行了测试，一种缺乏α和β麦醇溶蛋白，另一种缺乏α、β、γ和ω麦醇溶蛋白。在体外器官培养系统中，使用乳糜泻黏膜评估了这些小麦的胃蛋白酶-胰蛋白酶消化物。发现含有所有麦醇溶蛋白组分的面包小麦毒性明显较低。这些结果为乳糜泻的治疗提供了新的机会。
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