在细胞凋亡过程中会产生病毒抗原和自身抗原的新型包被物。
Novel packages of viral and self-antigens are generated during apoptosis.
作者信息
Rosen A, Casciola-Rosen L, Ahearn J
机构信息
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
J Exp Med. 1995 Apr 1;181(4):1557-61. doi: 10.1084/jem.181.4.1557.
Abstract
Immune context is an essential determinant of the host response to potential autoantigens. The clustering of the autoantigens targeted in systemic lupus erythematosus within surface blebs of apoptotic cells generates high concentrations of autoantigen within discrete subcellular packages. We demonstrate here that when apoptosis is induced by Sindbis virus infection, viral antigens and autoantigens cocluster exclusively in small surface blebs of apoptotic cells. The surface of these blebs is rich in viral glycoproteins, and virions can be seen blebbing from their surface. We propose that these blebs of mixed foreign and self-origin define a novel immune context that may challenge self-tolerance.
摘要
免疫环境是宿主对潜在自身抗原反应的重要决定因素。系统性红斑狼疮中靶向的自身抗原在凋亡细胞的表面小泡内聚集，在离散的亚细胞包裹中产生高浓度的自身抗原。我们在此证明，当由辛德毕斯病毒感染诱导细胞凋亡时，病毒抗原和自身抗原仅在凋亡细胞的小表面小泡中共聚集。这些小泡的表面富含病毒糖蛋白，并且可以看到病毒粒子从小泡表面出芽。我们提出，这些具有外来和自身来源的小泡定义了一种可能挑战自身耐受性的新型免疫环境。
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