Sprinkle R V
Department of Family Practice, University of California-Davis School of Medicine 95616, USA.
J Fam Pract. 1995 Apr;40(4):358-62.
Preventing lead exposure is of paramount importance because lead is significantly toxic at subclinical levels, and treating patients with elevated blood lead levels is difficult. Children were evaluated for lead exposure in California through a state-mandated lead screening program that was begun in November 1991. Imported eye cosmetics were identified as a suspected source of lead exposure for Pakistani and Indian children who used these products.
A retrospective chart review of children at a county hospital clinic was undertaken for the period beginning October 1991 and ending February 1994. Lead exposure questionnaires were filled out at clinic visits, and telephone interviews were conducted with parents or guardians of children from ethnic groups who use eye cosmetics.
Lead level results were available for 175 children. The average lead level was 4.3 micrograms/dL (0.21 mumol/L) for Pakistani/Indian children not using eye cosmetics and 12.9 micrograms/dL (0.62 mumol/L) (P = .03) for those using the products. Chemical evaluation of some of the eye cosmetics used by these children revealed high lead content.
Use of eye cosmetics imported from Pakistan was found to be strongly correlated with elevated blood lead levels. Although importation of leaded eye cosmetics is prohibited by law, legislation has not been effective in protecting children from this source of lead exposure. Education regarding low-level lead toxicity and avoidance of substances containing lead is needed, particularly for targeted subpopulations.
预防铅暴露至关重要,因为铅在亚临床水平就具有显著毒性,且治疗血铅水平升高的患者很困难。1991年11月起,加利福尼亚州通过一项州强制铅筛查项目对儿童进行铅暴露评估。进口眼部化妆品被确定为使用这些产品的巴基斯坦和印度儿童铅暴露的疑似来源。
对1991年10月至1994年2月期间一家县医院诊所的儿童进行回顾性病历审查。在诊所就诊时填写铅暴露问卷,并对使用眼部化妆品的族裔儿童的父母或监护人进行电话访谈。
有175名儿童的铅水平结果可供分析。未使用眼部化妆品的巴基斯坦/印度儿童的平均铅水平为4.3微克/分升(0.21微摩尔/升),使用这些产品的儿童平均铅水平为12.9微克/分升(0.62微摩尔/升)(P = .03)。对这些儿童使用的一些眼部化妆品进行化学评估发现铅含量很高。
发现使用从巴基斯坦进口的眼部化妆品与血铅水平升高密切相关。尽管法律禁止进口含铅眼部化妆品,但立法在保护儿童免受这种铅暴露来源方面并未有效。需要开展关于低水平铅毒性和避免使用含铅物质的教育,特别是针对目标亚人群。