Garcia-de la Torre I, Castello-Sendra J, Esgleyes-Ribot T, Martinez-Bonilla G, Guerrerosantos J, Fritzler M J
Department of Immunology and Rheumatology, Hospital General de Occidente de la Secretaria de Salud, Zapopan, Mexico.
J Rheumatol. 1995 Jan;22(1):73-7.
To determine autoantibody profiles of patients with Parry-Romberg syndrome (PRS).
Antinuclear antibodies (ANA) in 14 patients with PRS were studied by indirect immunofluorescence (IIF), immunodiffusion and immunoblotting. Antinative DNA antibodies and rheumatoid factor (RF) were also analyzed.
ANA were positive in 8 patients (57%). The patterns of staining included nucleolar, nuclear speckled and homogeneous. Anticentromere antibodies were observed in 2 and antihistone antibodies in 3 sera. Rheumatoid factor was found in 5 (36%) sera. Antinative DNA or antibodies that precipitated rabbit thymus extract were not found in any patients.
The serologic abnormalities observed in this study suggests that autoimmunity could play a pathogenic role in PRS.
确定帕里-罗默格综合征（PRS）患者的自身抗体谱。
采用间接免疫荧光法（IIF）、免疫扩散法和免疫印迹法对14例PRS患者的抗核抗体（ANA）进行研究。同时分析抗天然DNA抗体和类风湿因子（RF）。
8例患者（57%）ANA呈阳性。染色模式包括核仁型、核斑点型和均质型。在2份血清中观察到抗着丝点抗体，3份血清中观察到抗组蛋白抗体。5份（36%）血清中发现类风湿因子。所有患者均未发现抗天然DNA抗体或沉淀兔胸腺提取物的抗体。
本研究中观察到的血清学异常表明自身免疫可能在PRS的发病机制中起致病作用。
