Garcia-de la Torre I, Miranda-Mendez L
J Rheumatol. 1982 Jul-Aug;9(4):603-6.
Antinuclear antibodies (ANA) by the indirect immunofluorescence method and their immunospecificities were investigated in 60 patients with rheumatoid arthritis using HEp-2 cells as substrates. ANA were detected in 35% of the patients. The patterns of nuclear staining observed included: diffuse or patchy homogeneous (20%), speckled (8.3%), centromere (3.3%), nucleolar (1.6%) and in 1 patient a mixed pattern (1.6%). The presence of antihistone antibodies (20%) correlated with the presence of an homogeneous pattern on the HEp-2 cells.
采用间接免疫荧光法，以人喉癌上皮细胞（HEp-2细胞）为底物，对60例类风湿性关节炎患者的抗核抗体（ANA）及其免疫特异性进行了研究。35%的患者检测到ANA。观察到的核染色模式包括：弥漫性或斑片状均匀染色（20%）、斑点状（8.3%）、着丝粒（3.3%）、核仁（1.6%），1例患者为混合模式（1.6%）。抗组蛋白抗体的存在（20%）与HEp-2细胞上均匀染色模式的存在相关。
