Hryb D J, Khan M S, Romas N A, Rosner W
Department of Medicine, St. Luke's/Roosevelt Hospital Center, New York, N.Y. 10019.
Planta Med. 1995 Feb;61(1):31-2. doi: 10.1055/s-2006-957993.
Extracts from the roots of the stinging nettle (Urtica dioica) are used in the treatment of benign prostatic hyperplasia. The mechanisms underlying this treatment have not been elucidated. We set out to determine whether specific extracts from U. dioica had the ability to modulate the binding of sex hormone-binding globulin to its receptor on human prostatic membranes. Four substances contained in U. dioica were examined: an aqueous extract; an alcoholic extract; U. dioica agglutinin, and stigmasta-4-en-3-one. Of these, only the aqueous extract was active. It inhibited the binding of 125I-SHBG to its receptor. The inhibition was dose related, starting at about 0.6 mg/ml and completely inhibited binding at 10 mg/ml.
荨麻（Urtica dioica）根提取物用于治疗良性前列腺增生。这种治疗的潜在机制尚未阐明。我们着手确定荨麻的特定提取物是否有能力调节性激素结合球蛋白与其在人前列腺膜上的受体的结合。检测了荨麻中含有的四种物质：水提取物；醇提取物；荨麻凝集素和豆甾-4-烯-3-酮。其中，只有水提取物具有活性。它抑制了125I-SHBG与其受体的结合。这种抑制作用与剂量相关，起始浓度约为0.6mg/ml，在10mg/ml时完全抑制结合。
