Weniger B, Italiano L, Beck J P, Bastida J, Bergoñon S, Codina C, Lobstein A, Anton R
Planta Med. 1995 Feb;61(1):77-9. doi: 10.1055/s-2006-958007.
25 Amaryllidaceae alkaloids belonging to different skeletal types were evaluated for their cytotoxic activity against one murine non-tumoral cell line (LMTK) and two human tumoral cell lines (Molt4 and HepG2) according to established protocols. Significant differences of activity related with the type of skeleton of the tested alkaloids could be observed. Pretazettine (22) was among the most active compound among the 25 tested alkaloids on the Molt4 lymphoid cells, but was inactive against HepG2 hepatoma. On the other hand, lycorenine (11) was found to be the most cytotoxic compound against HepG2 hepatoma, even though it appears to be active against Molt4 cells. Almost all of the tested alkaloids showed cytotoxic activity against fibroblastic LMTK cells. Only mesembrenone (25) showed some specificity against Molt4 cells in comparison to LMTK cells.
根据既定方案，对25种属于不同骨架类型的石蒜科生物碱进行了评估，以检测它们对一种小鼠非肿瘤细胞系（LMTK）和两种人类肿瘤细胞系（Molt4和HepG2）的细胞毒性活性。可以观察到，所测试生物碱的活性与骨架类型存在显著差异。前多花水仙碱（22）是25种测试生物碱中对Molt4淋巴细胞活性最高的化合物之一，但对HepG2肝癌细胞无活性。另一方面，石蒜伦碱（11）被发现是对HepG2肝癌细胞毒性最大的化合物，尽管它似乎对Molt4细胞也有活性。几乎所有测试的生物碱都对成纤维细胞LMTK细胞显示出细胞毒性活性。与LMTK细胞相比，只有美登木酮（25）对Molt4细胞表现出一定的特异性。
