Teahon K, Pearson M, Smith T, Bjarnason I
Dept. of Clinical Pharmacology, University of Newcastle-upon-Tyne, UK.
Scand J Gastroenterol. 1995 Jan;30(1):54-60. doi: 10.3109/00365529509093236.
The mechanisms by which elemental diets induce remission in patients with Crohn's disease is unknown, but it has been suggested that improvement in nutritional state may play a part.
We assessed sequential changes in disease activity (clinical and laboratory indices and faecal excretion of indium-111-labelled leucocytes) and nutritional status (anthropometry, body composition variables), hepatic secretory proteins (albumin, pre-albumin, transferrin), and trace elements (iron, magnesium, copper, zinc) during treatment of acute Crohn's disease with an elemental diet.
Disease activity indices improved significantly by 2 weeks and were maintained at 4 weeks of treatment. There was a significant increase in pre-albumin at 4 weeks and an increase in serum iron and a decrease in serum copper during the study period. The changes occurring in the measures of nutrition did not correlate significantly with the changes in disease activity.
The fact that changes in disease activity appear to precede any detectable changes in nutritional state, it suggests that the beneficial action of elemental diet in patients with active Crohn's disease is not due to an improvement in nutritional status.
要素饮食促使克罗恩病患者病情缓解的机制尚不清楚，但有观点认为营养状况的改善可能起到一定作用。
我们评估了在用要素饮食治疗急性克罗恩病期间，疾病活动度（临床和实验室指标以及铟-111标记白细胞的粪便排泄情况）、营养状况（人体测量学、身体成分变量）、肝脏分泌蛋白（白蛋白、前白蛋白、转铁蛋白）以及微量元素（铁、镁、铜、锌）的连续变化。
疾病活动度指标在2周时显著改善，并在治疗4周时维持稳定。在研究期间，前白蛋白在4周时有显著增加，血清铁增加，血清铜减少。营养指标的变化与疾病活动度的变化无显著相关性。
疾病活动度变化似乎先于营养状况的任何可检测到的变化，这表明要素饮食对活动期克罗恩病患者的有益作用并非源于营养状况改善。
