Boezen H M, Schouten J P, Postma D S, Rijcken B
Department of Epidemiology and Statistics, University of Groningen, The Netherlands.
Thorax. 1995 Feb;50(2):121-6. doi: 10.1136/thx.50.2.121.
A study was carried out to determine whether subjects with respiratory symptoms are more likely to have impaired lung function or increased airway lability, and to quantify these relationships in a population of adults.
Data were collected from 511 participants (aged 20-70 years) from the Dutch part of the European Community Respiratory Health Survey (ECRHS). The symptoms analysed were: wheeze, dyspnoea > or = grade 3, nocturnal dyspnoea, cough and phlegm, and history of allergy. Lung function was measured by peak expiratory flow (PEF) and forced expiratory volume in one second (FEV1). PEF variability was used as an index for bronchial lability.
Both FEV1 and PEF were decreased with increasing numbers of symptoms. Subjects with one symptom had an increased risk of having an FEV1 value of < 70% (OR = 4.2) and this risk increased with an increasing number of symptoms. Subjects with three or more symptoms had an increased risk of having a PEF value of < 70%, a diurnal variation in PEF of > 10% (both OR = 4.4), and an increased risk of high between day variation (OR = 6.6).
Subject-reported symptoms are related to impaired lung function and to increased variability of peak flow.
开展了一项研究，以确定有呼吸道症状的受试者是否更有可能存在肺功能受损或气道易激性增加的情况，并在成年人群体中对这些关系进行量化。
从欧洲共同体呼吸健康调查（ECRHS）荷兰部分的511名参与者（年龄在20 - 70岁之间）收集数据。分析的症状包括：喘息、呼吸困难≥3级、夜间呼吸困难、咳嗽和咳痰以及过敏史。通过呼气峰值流速（PEF）和一秒用力呼气容积（FEV1）来测量肺功能。PEF变异性被用作支气管易激性的指标。
随着症状数量的增加，FEV1和PEF均降低。有一个症状的受试者FEV1值<70%的风险增加（比值比[OR]=4.2），且该风险随着症状数量的增加而增加。有三个或更多症状的受试者PEF值<70%、PEF日间变化>10%的风险均增加（OR均为4.4），日间高变异性的风险也增加（OR = 6.6）。
受试者报告的症状与肺功能受损以及峰值流速变异性增加有关。
