酵母中交配型区域对交配和减数分裂的调控
Regulation of mating and meiosis in yeast by the mating-type region.
作者信息
Kassir Y, Simchen G
出版信息
Genetics. 1976 Feb;82(2):187-206. doi: 10.1093/genetics/82.2.187.
Abstract
A supposed sporulation-deficient mutation of Saccharomyces cerevisiae is found to affect mating in haploids and in diploids, and to be inseparable from the mating-type locus by recombination. The mutation is regarded as a defective a allele and is designated a*. This is confirmed by its dominance relations in diploids, triploids, and tetraploids. Tetrad analysis of tetraploids and of their sporulating diploid progeny suggests the existence of an additional locus, RME, which regulates sporulation in yeast strains that can mate. Thus the recessive homozygous constitution rme/rm- enables the diploids a*/alpha, a/a*, and alpha/alpha to go through meiosis. Haploids carrying rme show apparent premeiotic DNA replication in sporulation conditions. This new regulatory locus is linked to the centromere of the mating-type chromosome, and its two alleles, rme and RME, are found among standard laboratory strains.
摘要
人们发现，酿酒酵母中一个假定的孢子形成缺陷型突变会影响单倍体和二倍体的交配，并且通过重组与交配型基因座不可分离。该突变被视为有缺陷的a等位基因，并被命名为a*。这在其二倍体、三倍体和四倍体中的显性关系中得到了证实。对四倍体及其产孢二倍体后代的四分体分析表明，存在一个额外的基因座RME，它调节可交配酵母菌株中的孢子形成。因此，隐性纯合基因型rme/rm-能使二倍体a*/α、a/a*和α/α进行减数分裂。携带rme的单倍体在孢子形成条件下表现出明显的减数分裂前DNA复制。这个新的调控基因座与交配型染色体的着丝粒相连，并且在标准实验室菌株中发现了它的两个等位基因rme和RME。
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