Williams C, Papakostopoulos D
Electrodiagnostic Department, Bristol Eye Hospital.
Br J Ophthalmol. 1995 Mar;79(3):218-24. doi: 10.1136/bjo.79.3.218.
Electrodiagnostic tests have been used to investigate retinal function in amblyopia but previous results have been conflicting.
It was decided to investigate whether the electro-oculogram (EOG) showed any abnormalities in 12 adult amblyopes and 12 age and sex matched controls with normal vision. The mean amplitudes of the EOG recordings from each eye during 12 minutes of darkness and 18 minutes of light were compared.
The mean values from the amblyopic eyes were lower than those from the fellow non-amblyopic eyes. At most time points the difference was significant (p < 0.05). After normalisation of the data to minimise intersubject variation, the reduction in EOG amplitudes of the amblyopic eyes at all time points was significant (p < 0.05). There was no significant difference between the mean values obtained from the right and left control eyes at any time point, either before or after normalisation.
These results provide evidence for a retinal abnormality in amblyopia and implicate the retinal pigment epithelium as being involved. A deficiency in retinal dopaminergic function in amblyopia is proposed as a possible mechanism causing these results.
电诊断测试已被用于研究弱视患者的视网膜功能，但先前的结果存在矛盾。
决定对12名成年弱视患者以及12名年龄和性别相匹配、视力正常的对照者进行眼电图（EOG）检查，以探究其是否存在异常。比较了每只眼睛在12分钟黑暗和18分钟光照期间EOG记录的平均振幅。
弱视眼的平均值低于对侧非弱视眼。在大多数时间点，差异具有统计学意义（p < 0.05）。对数据进行标准化以最小化个体间差异后，弱视眼在所有时间点的EOG振幅降低均具有统计学意义（p < 0.05）。在标准化前后的任何时间点，左右对照眼获得的平均值之间均无显著差异。
这些结果为弱视患者视网膜异常提供了证据，并表明视网膜色素上皮参与其中。提出弱视患者视网膜多巴胺能功能缺陷是导致这些结果的一种可能机制。
