Ferruti P, Ranucci E, Sartore L, Bignotti F, Marchisio M A, Bianciardi P, Veronese F M
Dipartimento di Chimica e Fisica per i Materiali, Università di Brescia, Italy.
Biomaterials. 1994 Dec;15(15):1235-41. doi: 10.1016/0142-9612(94)90275-5.
Different families of functionalized polymers with potential as biomaterials, or for biomaterial modification, have been investigated. In particular, degradation studies have been performed on poly(amidoamines), a family of polymers obtained by polyaddition of amines to bisacrylamides, and endowed with heparin-complexing ability. Some new poly(amidoamines) with more resistance towards hydrolytic degradation than traditional ones have been discovered. Other ter-amino polymers deriving from the polyaddition of ter-amino functionalized bis-thiols to bis-acrylic esters, or other activated unsaturated compounds, have been studied. Their quaternarization products have been proven, in a parallel work, to act as powerful antimicrobial agents. By performing in situ the polyaddition reaction, semi-interpenetrated networks based on silicone rubber and the same polymers have been prepared. Finally, end-functionalized amphiphilic oligomers have been prepared by radical polymerization techniques, and their use for enzyme modification considered.
人们已经研究了具有生物材料潜力或用于生物材料改性的不同功能化聚合物家族。特别是，已经对聚（酰胺胺）进行了降解研究，聚（酰胺胺）是一类通过胺与双丙烯酰胺加成聚合得到的聚合物，具有肝素络合能力。已经发现了一些比传统聚（酰胺胺）更耐水解降解的新型聚（酰胺胺）。还研究了由三氨基官能化双硫醇与双丙烯酸酯或其他活性不饱和化合物加成聚合得到的其他三氨基聚合物。在一项平行研究中，已证明它们的季铵化产物可作为强大的抗菌剂。通过原位进行加成聚合反应，制备了基于硅橡胶和相同聚合物的半互穿网络。最后，通过自由基聚合技术制备了末端官能化的两亲性低聚物，并考虑了它们在酶修饰中的应用。
