Palmer A M, Marion D W, Botscheller M L, Bowen D M, DeKosky S T
Department of Psychiatry, University of Pittsburgh School of Medicine, USA.
Neuroreport. 1994 Dec 30;6(1):153-6. doi: 10.1097/00001756-199412300-00039.
The concentrations of L-aspartate, L-glutamate, L-serine, glycine and gamma-aminobutyric acid (GABA) were determined in repeated samples of ventricular CSF from five patients with severe closed head injury. The values were compared with those obtained from five subjects undergoing surgical treatment for intractable depression. In the head-injured patients, the concentrations of aspartate, glutamate and glycine were 2- to 8-fold higher and the concentration of GABA 56- to 317-fold higher than control values; the concentration of serine was unaffected. Spearman correlation analysis indicated that the concentration of glutamate significantly increased after injury (Rs = 0.60, p < 0.0001, n = 42), reaching an average concentration of about 7 microM 3 days after the injury. This is probably sufficient to cause further excitotoxicity, which suggests the use of excitatory amino acid receptor antagonists as a treatment following severe head injury may require prolonged administration for maximum therapeutic benefit.
测定了5例重度闭合性颅脑损伤患者脑室脑脊液重复样本中L-天冬氨酸、L-谷氨酸、L-丝氨酸、甘氨酸和γ-氨基丁酸（GABA）的浓度。将这些值与5例接受顽固性抑郁症手术治疗的受试者的值进行比较。在颅脑损伤患者中，天冬氨酸、谷氨酸和甘氨酸的浓度比对照值高2至8倍，GABA的浓度比对照值高56至317倍；丝氨酸的浓度未受影响。Spearman相关性分析表明，损伤后谷氨酸浓度显著升高（Rs = 0.60，p < 0.0001，n = 42），损伤后3天平均浓度达到约7 microM。这可能足以导致进一步的兴奋性毒性，这表明在重度颅脑损伤后使用兴奋性氨基酸受体拮抗剂作为治疗方法可能需要长期给药以获得最大治疗益处。
