氧自由基与石棉致癌作用
Oxygen radicals and asbestos carcinogenesis.
作者信息
Moyer V D, Cistulli C A, Vaslet C A, Kane A B
机构信息
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.
出版信息
Environ Health Perspect. 1994 Dec;102 Suppl 10(Suppl 10):131-6. doi: 10.1289/ehp.94102s10131.
Abstract
Asbestos fibers have been shown to generate reactive oxygen species using a variety of in vitro assays. It is hypothesized that these highly reactive metabolites mediate the development of malignant mesothelioma induced by asbestos fibers. DNA is a potential target of oxidant attack. Adaptive responses to oxidant injury have been described during exposure of mesothelial cells to asbestos fibers in vitro. Failure of these adaptive responses may lead to genetic instability and alterations in oncogenes and tumor suppressor genes that confer a proliferative advantage to emerging neoplastic mesothelial cells.
摘要
使用各种体外试验已表明石棉纤维会产生活性氧物种。据推测，这些高反应性代谢产物介导了石棉纤维诱发的恶性间皮瘤的发展。DNA是氧化损伤的一个潜在靶点。在体外将间皮细胞暴露于石棉纤维的过程中，已描述了对氧化损伤的适应性反应。这些适应性反应的失败可能导致基因不稳定以及癌基因和肿瘤抑制基因的改变，从而赋予新出现的肿瘤性间皮细胞增殖优势。
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