Kee B L, Paige C J
Wellesley Hospital Research Institute, Toronto, Ontario, Canada.
Int Rev Cytol. 1995;157:129-79. doi: 10.1016/s0074-7696(08)62158-0.
B lymphocytes, the cellular source of antibody, are critical components of the immune response. They develop from multipotential stem cells, progressively acquiring the traits that allow them to function as mature B lymphocytes. This developmental program is dependent on appropriate interactions with the surrounding environment. These interactions, mediated by cell-cell and cell-matrix interactions, provide the growth and differentiation signals that promote progression along the developmental pathway. This chapter addresses the properties of developing B lineage cells and the nature of the environmental signals that support B lineage progression.
B淋巴细胞是抗体的细胞来源，是免疫反应的关键组成部分。它们从多能干细胞发育而来，逐渐获得使其能够作为成熟B淋巴细胞发挥功能的特性。这个发育程序依赖于与周围环境的适当相互作用。这些相互作用由细胞间和细胞与基质的相互作用介导，提供促进沿发育途径进展的生长和分化信号。本章阐述了发育中的B系细胞的特性以及支持B系进展的环境信号的性质。
