Schirren C G, Rütten A, Sander C, McClain S, Diaz C, Kind P
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1995 Feb;46(2):81-6. doi: 10.1007/s001050050214.
The purpose of this article is to inform about neoplasms with follicular differentiation, particularly trichoblastoma. In 1970 Headington divided neoplasms of the hair germ (trichogenic tumours) into four groups: purely epithelial without inductive changes (trichoblastomas), mixed epithelial-mesenchymal with inductive changes (trichoblastic fibromas), mixed epithelial-mesenchymal with inductive changes and advanced hair follicle formations (trichogenic trichoblastomas), and predominantly mesenchymal with an abortive dermal hair papilla (trichogenic myxoma). Meanwhile a new classification of neoplasms with follicular differentiation has been presented, according to which every neoplasm with follicular differentiation, benign structure (symmetrical, circumscribed, with vertical growth), and predominance of follicular germinative cells is called a trichoblastoma. Whether this neoplasm is malignant and if so to what degree is under discussion. This classification is gaining in acceptance among histopathologists but has not been accepted in the field of clinical dermatology.
本文旨在介绍具有毛囊分化的肿瘤，尤其是毛母细胞瘤。1970年，海丁顿将毛胚肿瘤（毛发发生肿瘤）分为四组：无诱导性改变的纯上皮性肿瘤（毛母细胞瘤）、有诱导性改变的混合上皮-间充质肿瘤（毛母细胞纤维瘤）、有诱导性改变及高级毛囊形成的混合上皮-间充质肿瘤（毛发发生性毛母细胞瘤），以及以发育不全的真皮毛乳头为主的间充质肿瘤（毛发发生性黏液瘤）。同时，一种新的具有毛囊分化的肿瘤分类方法已经提出，根据该方法，每一种具有毛囊分化、良性结构（对称、边界清楚、垂直生长）且毛囊生发细胞占优势的肿瘤都称为毛母细胞瘤。该肿瘤是否为恶性以及如果是恶性其程度如何仍在讨论中。这种分类方法在组织病理学家中越来越被接受，但在临床皮肤科领域尚未被接受。
