Headington J T
J Clin Pathol. 1970 Sep;23(6):464-71. doi: 10.1136/jcp.23.6.464.
Differentiating neoplasms of hair germ are benign epithelial-mesenchymal tumours of skin in which hair follicle development may be partly or completely recapitulated. The epithelial component is equivalent to the hair germ. The mesenchymal component is equivalent to the dermal papilla. Epithelial-mesenchymal interaction results in the morphogenesis of hair follicles. In neoplasms showing stromal induction, there is centrifugal organizations: hair bulbs are found at the periphery of tumour lobules and hairs are projected centrally to lie within small keratinizing cysts. Neoplasms of hair germ without advanced morpho-differentiation are termed ;trichoblastomas', and those neoplasms in which hair follicle development is advanced are called ;trichogenic trichoblastomas'.
毛母质瘤是皮肤的良性上皮-间叶肿瘤,其中毛囊发育可能部分或完全重现。上皮成分相当于毛母质,间叶成分相当于毛乳头。上皮-间叶相互作用导致毛囊形态发生。在显示间质诱导的肿瘤中,存在离心性结构:毛球位于肿瘤小叶的周边,毛发向中心突出并位于小的角化囊肿内。未发生高级形态分化的毛母质瘤称为“成毛细胞瘤”,而毛囊发育进展的肿瘤称为“毛发生成性成毛细胞瘤”。