Schirren C G, Rütten A, Plewig G
Dermatologische Klinik und Poliklinik, Ludwig-Maximillians-Universität, München.
Hautarzt. 1996 Aug;47(8):610-5. doi: 10.1007/s001050050477.
Panfolliculoma is a rare benign neoplasm showing morphological similarities to the trichogenic trichoblastoma of Headington and the trichoblastoma of Ackerman. Eight patients have been previously reported; we add four additional patients. Their ages ranged from the 2nd to the 6th decade. The neoplasms were primarily situated on the head and the trunk. Clinical examination revealed a skin colored or red, dermal cystic nodule. The histological appearance of the panfolliculoma was characterized by symmetry, sharp circumscription and regular aggregations of cells, which were in parts solid or cystic. Additionally, follicular germs and papillae, matrical, inner and outer rooth sheath differentiation were identified. These varied forms of follicular differentiation were confirmed by the immunohistochemical expression of cytokeratins in different epithelial cells. Panfolliculoma is a benign neoplasm with proven morphological and immunhistochemical follicular differentiation.
全毛囊瘤是一种罕见的良性肿瘤，在形态学上与海丁顿的毛发源性毛母细胞瘤及阿克曼的毛母细胞瘤相似。此前已报道过8例患者；我们又增加了4例患者。他们的年龄在20岁至60岁之间。肿瘤主要位于头部和躯干。临床检查发现为肤色或红色的真皮囊性结节。全毛囊瘤的组织学表现特征为对称性、边界清晰以及细胞规则聚集，部分呈实性或囊性。此外，还发现了毛囊胚芽、乳头、毛母质、内根鞘和外根鞘分化。不同上皮细胞中细胞角蛋白的免疫组化表达证实了这些不同形式的毛囊分化。全毛囊瘤是一种已证实具有形态学和免疫组化毛囊分化的良性肿瘤。
