Law D, Moore C B, Wardle H M, Ganguli L A, Keaney M G, Denning D W
Department of Microbiology, University of Manchester, Hope Hospital, Salford, UK.
J Antimicrob Chemother. 1994 Nov;34(5):659-68. doi: 10.1093/jac/34.5.659.
Three hundred and forty-eight isolates of Candida spp. from patients treated at a regional infectious diseases unit for AIDS, immunocompromised patients admitted to the Hope Hospital and isolates referred from around the North West of England were tested for their in-vitro susceptibility to amphotericin B, fluconazole and flucytosine using standardized methods. Candida albicans comprised 73% of isolates, Candida glabrata 10% and Candida parapsilosis 7%. Ninety-six percent of isolates were susceptible to amphotericin B and resistance to > or = 12.5 mg/L fluconazole was found in 61 (17.5%) of the 348 isolates tested. Among isolates from patients with AIDS the incidence of fluconazole resistance was 33% whereas in other patients the incidence was only 11%. Flucytosine resistance was seen in only 12 (3.4%) isolates, 11 of which were C. albicans and in 6.5% of isolates from patients with AIDS. Resistance to fluconazole and flucytosine is now sufficiently prevalent among Candida spp. isolated from patients with AIDS to warrant routine susceptibility testing of yeast isolates.
采用标准化方法，对从一家地区传染病科接受治疗的艾滋病患者、霍普医院收治的免疫功能低下患者以及从英格兰西北部各地转诊而来的患者中分离出的348株念珠菌属菌株，进行了两性霉素B、氟康唑和氟胞嘧啶的体外药敏试验。白色念珠菌占分离菌株的73%，光滑念珠菌占10%，近平滑念珠菌占7%。96%的分离菌株对两性霉素B敏感，在348株受试菌株中，有61株（17.5%）对≥12.5mg/L氟康唑耐药。在艾滋病患者的分离菌株中，氟康唑耐药率为33%，而在其他患者中，这一比例仅为11%。仅12株（3.4%）分离菌株对氟胞嘧啶耐药，其中11株为白色念珠菌，在艾滋病患者的分离菌株中，这一比例为6.5%。目前，从艾滋病患者中分离出的念珠菌属菌株对氟康唑和氟胞嘧啶的耐药情况已相当普遍，因此有必要对酵母分离株进行常规药敏试验。
