脓毒症与炎症反应机制：运动是一个好的模型吗？
Sepsis and mechanisms of inflammatory response: is exercise a good model?
作者信息
Shephard R J
机构信息
Faculty of Physical Education and Health and Department of Public Health Sciences, University of Toronto and Defence and Civil Institute of Environmental Medicine, Toronto, Ontario, Canada.
出版信息
Br J Sports Med. 2001 Aug;35(4):223-30. doi: 10.1136/bjsm.35.4.223.
OBJECTIVES
The immune changes induced by a bout of prolonged and vigorous exercise have been suggested to be a useful experimental model of sepsis and the inflammatory response. Available literature was reviewed to evaluate this hypothesis.
METHODS
Literature describing the immune response to various patterns of exercise was compared with data on the immune changes observed during sepsis and inflammation.
RESULTS
Although there are qualitative similarities between the immune responses to exercise and sepsis, the magnitude of the changes induced by most forms of exercise remains much smaller than in a typical inflammatory response. Indeed, the exercise induced changes in some key elements such as plasma cytokine concentrations are too small to be detected reliably by current technology.
CONCLUSIONS
If exercise is to provide a valid model of sepsis and the inflammatory response, it will be necessary to focus on subjects who are willing to exercise extremely hard, to use the pattern of exercise that has the greatest effect on the immune system, and to combine this stimulus with other psychological, environmental, or nutritional stressors.
目的
长时间剧烈运动引发的免疫变化被认为是脓毒症及炎症反应的一种有用实验模型。对现有文献进行综述以评估这一假设。
方法
将描述对各种运动模式的免疫反应的文献与脓毒症和炎症期间观察到的免疫变化数据进行比较。
结果
尽管运动和脓毒症的免疫反应在性质上有相似之处，但大多数运动形式引起的变化程度仍远小于典型的炎症反应。事实上，运动引起的一些关键因素的变化，如血浆细胞因子浓度，太小以至于目前技术无法可靠检测到。
结论
如果运动要成为脓毒症和炎症反应的有效模型，就有必要关注那些愿意进行极剧烈运动的受试者，采用对免疫系统影响最大的运动模式，并将这种刺激与其他心理、环境或营养应激源相结合。
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