Raben D M, Jarpe M B, Leach K L
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
J Membr Biol. 1994 Oct;142(1):1-7. doi: 10.1007/BF00233378.
There is increasing evidence that nuclear lipid metabolism in NEST is an important new component in signal transducing networks and as a result, this metabolism is beginning to attract more attention. While agonist-induced nuclear lipid metabolism adds further complexity to the ever increasing array of signal transduction components, it also provides further avenues by which nuclear activities may be regulated. Identification of the coupling mechanisms, regulation, and physiological roles of nuclear lipid metabolism represents a new and exciting area of research which will have a broad impact in our understanding of signal transduction pathways.
越来越多的证据表明，细胞核内的脂质代谢是信号转导网络中一个重要的新组成部分，因此，这种代谢开始受到更多关注。虽然激动剂诱导的细胞核脂质代谢给不断增加的信号转导成分阵列增添了更多复杂性，但它也提供了调节核活动的更多途径。确定细胞核脂质代谢的偶联机制、调节及其生理作用代表了一个新的、令人兴奋的研究领域，这将对我们理解信号转导途径产生广泛影响。
