Lakin N D, Palmer R, Lillycrop K A, Howard M K, Burke L C, Thomas N S, Latchman D S
Department of Molecular Pathology, University College London Medical School, UK.
Brain Res Mol Brain Res. 1995 Jan;28(1):47-54. doi: 10.1016/0169-328x(94)00183-f.
The octamer binding transcription/DNA replication factor Oct-1 is present in virtually all cell types including proliferating cell lines of neuronal origin but is not detectable in mature non-dividing neurons. Cell cycle arrest in G0/G1 and morphological differentiation of a neuronal cell line is accompanied by a decline in the level of Oct-1 DNA binding, although the level of DNA binding by another octamer binding protein, Oct-2 is unaltered. This effect is paralled by a decline in the level of the Oct-1 mRNA in the non-dividing cells. The decrease in Oct-1 levels occurs only with the production of a mature, non-dividing neuronal phenotype and not when the cells are arrested in late G1 and do not undergo morphological differentiation. The potential role of Oct-1 and other octamer binding proteins in gene regulation in neuronal cells and in their differentiation is discussed.
八聚体结合转录/DNA复制因子Oct-1几乎存在于所有细胞类型中，包括神经元来源的增殖细胞系，但在成熟的非分裂神经元中无法检测到。神经元细胞系在G0/G1期的细胞周期停滞和形态分化伴随着Oct-1 DNA结合水平的下降，尽管另一种八聚体结合蛋白Oct-2的DNA结合水平未改变。这种效应与非分裂细胞中Oct-1 mRNA水平的下降平行。Oct-1水平的降低仅在成熟的非分裂神经元表型产生时出现，而当细胞停滞在G1晚期且未发生形态分化时则不会出现。本文讨论了Oct-1和其他八聚体结合蛋白在神经元细胞基因调控及其分化中的潜在作用。
