Gonzàlez R, Ancheta O, Màrquez M, Rodriguez S
Department of Pharmacology, National Center for Scientific Research, Ciudad Habana, Cuba.
Zhongguo Yao Li Xue Bao. 1994 Nov;15(6):495-7.
This research was carried out to determine a potential role of leukotrienes in the acute hepatotoxicity induced by CCl4 in rats. An inhibitor of leukotrienes biosynthesis, diethylcarbamazine (DEC, 25 and 50 mg.kg-1 ip) exerted hepatoprotective effects, decreasing the activity of alanine aminotransferase in serum and the concentration of liver triglycerides. DEC reduced histological damage of liver evidenced by electron microscopy. The hepatoprotective effects of DEC were dose-dependent. The results favor the role of leukotrienes in CCl4 hepatotoxicity.
本研究旨在确定白三烯在四氯化碳诱导的大鼠急性肝毒性中的潜在作用。白三烯生物合成抑制剂二乙氨基甲嗪（DEC，25和50mg·kg-1，腹腔注射）发挥了肝保护作用，降低了血清中丙氨酸转氨酶的活性以及肝脏甘油三酯的浓度。DEC减轻了电子显微镜所证实的肝脏组织学损伤。DEC的肝保护作用呈剂量依赖性。这些结果支持白三烯在四氯化碳肝毒性中的作用。
