Xu S B, Chen W F, Liang H Q, Lin Y C, Deng Y J, Long K H
Department of Biology, Sunyatsen University, Guangzhou, China.
Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):376-8.
Blumeatin (Blu, 5,3',5'-trihydroxy-7-methoxy-dihydro-flavone) was first isolated from Blumea balsamifera DC by Department of Chemistry, Sunyatsen University of China. Blu ip inhibited the increase of serum alanine aminotransferase (AAT) and liver triglyceride and increased serum triglyceride, beta-lipoprotein, and liver glycogen content in CCl4-intoxicated rats. Histological lesions of liver were less severe than those of hepatic injury control. Blu ip 0.65 and 3.25 mg.kg-1 inhibited the increase of serum AAT and hepatic TG in thioacetamide (TAA)-intoxicated mice. Blu ip shortened the pentobarbital sleeping time in CCl4-intoxicated mice. It suggested that Blu could protect liver against injury induced by CCl4 and TAA.
艾黄素（Blu，5,3'，5'-三羟基-7-甲氧基-二氢黄酮）最初是由中国中山大学化学系从大风艾中分离得到的。在四氯化碳中毒的大鼠中，腹腔注射艾黄素可抑制血清丙氨酸氨基转移酶（AAT）和肝脏甘油三酯的升高，并增加血清甘油三酯、β-脂蛋白和肝脏糖原含量。肝脏的组织学损伤比肝损伤对照组轻。腹腔注射0.65和3.25mg·kg-1的艾黄素可抑制硫代乙酰胺（TAA）中毒小鼠血清AAT和肝脏甘油三酯的升高。腹腔注射艾黄素可缩短四氯化碳中毒小鼠的戊巴比妥睡眠时间。这表明艾黄素可以保护肝脏免受四氯化碳和硫代乙酰胺诱导的损伤。
