Starkstein S E, Vázquez S, Migliorelli R, Tesón A, Sabe L, Leiguarda R
Department of Behavioral Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
Arch Neurol. 1995 Apr;52(4):415-20. doi: 10.1001/archneur.1995.00540280105024.
To examine the presence of specific regional cerebral blood flow correlates of anosognosia in patients with probable Alzheimer's disease.
Case series, group comparisons.
Ambulatory care referral center.
Twelve patients with probable Alzheimer's disease and anosognosia and 12 patients with probable Alzheimer's disease without anosognosia who were matched for age, duration of illness, and cognitive impairments.
Single-photon emission computed tomographic scan studies with technetium Tc 99m hexamethylpropylene-amine oxime and regional cerebral blood flow measurements.
Patients with Alzheimer's disease and anosognosia showed significant blood flow deficits in the frontal inferior and superior (dorsal) areas of the right hemisphere. On the other hand, no significant between-group differences were found in depression scores and neuropsychological tasks that assessed verbal and visual memory, verbal comprehension, naming, verbal fluency, auditory attention, abstract reasoning, and set-shifting abilities.
Our study demonstrates that anosognosia may not be related to deficits in specific cognitive domains, but it may result from dysfunction of the right frontal lobe.
研究可能患有阿尔茨海默病的患者中失认症与特定区域脑血流之间的相关性。
病例系列研究，组间比较。
门诊护理转诊中心。
12例可能患有阿尔茨海默病且伴有失认症的患者，以及12例可能患有阿尔茨海默病但无失认症的患者，两组患者在年龄、病程和认知障碍方面相匹配。
使用锝Tc 99m六甲基丙烯胺肟进行单光子发射计算机断层扫描研究及区域脑血流测量。
患有阿尔茨海默病且伴有失认症的患者右半球额叶下部和上部（背侧）区域存在明显的血流不足。另一方面，在抑郁评分以及评估言语和视觉记忆、言语理解、命名、言语流畅性、听觉注意力、抽象推理和转换能力的神经心理学任务方面，未发现组间存在显著差异。
我们的研究表明，失认症可能与特定认知领域的缺陷无关，而可能是由右额叶功能障碍导致的。
