Rodríguez A D, Cóbar O M, Martínez N
Department of Chemistry, University of Puerto Rico, U.P.R. Station, Río Piedras 00931-3346.
J Nat Prod. 1994 Dec;57(12):1638-55. doi: 10.1021/np50114a005.
Sixteen new diterpenoids, representative of the asbestinane skeletal class, have been isolated from shallow water colonies of the Caribbean gorgonian octocoral Briareum asbestinum. The structures of these secondary metabolites, named asbestinin-11 [1], asbestinin-12 [3], asbestinin-13 [4], asbestinin-14 [5], asbestinin-15 [7], asbestinin-16 [8], asbestinin-17 [9], asbestinin-18 [10], asbestinin-19 [11], asbestinin-20 [12], asbestinin-21 [13], asbestinin-22 [14], asbestinin-23 [15], 11-acetoxy-4-deoxyasbestinin E [16], 11-acetoxy-4-deoxyasbestinin F [17] and 4-deoxyasbestinin G [18], were defined by chemical and spectroscopic methods. These specimens of B. asbestinum, collected in Puerto Rico, yielded almost exclusively diterpenoids possessing the asbestinane carbon skeleton thus suggesting minor biosynthetic variations for this gorgonian. In this paper, we also revise the structures of the known asbestinin-6 and asbestinin-7 to asbestinanes 2 and 6, respectively.
从加勒比海柳珊瑚Briareum asbestinum的浅水群体中分离出了16种新的二萜类化合物，它们是石棉烷骨架类的代表。这些次生代谢产物的结构，命名为石棉素-11 [1]、石棉素-12 [3]、石棉素-13 [4]、石棉素-14 [5]、石棉素-15 [7]、石棉素-16 [8]、石棉素-17 [9]、石棉素-18 [10]、石棉素-19 [11]、石棉素-20 [12]、石棉素-21 [13]、石棉素-22 [14]、石棉素-23 [15]、11-乙酰氧基-4-脱氧石棉素E [16]、11-乙酰氧基-4-脱氧石棉素F [17]和4-脱氧石棉素G [18]，通过化学和光谱方法确定。这些在波多黎各收集的B. asbestinum标本几乎只产生了具有石棉烷碳骨架的二萜类化合物，这表明这种柳珊瑚的生物合成变化较小。在本文中，我们还将已知的石棉素-6和石棉素-7的结构分别修订为石棉烷2和6。
