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海洋抗肿瘤剂：14-脱氧克拉辛和假普雷克索醇，来自加勒比海柳珊瑚多孔拟柳珊瑚的新西松烷型二萜类化合物。

Marine antitumor agents: 14-deoxycrassin and pseudoplexaurol, new cembranoid diterpenes from the Caribbean gorgonian Pseudoplexaura porosa.

作者信息

Rodríguez A D, Martínez N

机构信息

Department of Chemistry, University of Puerto Rico, Río Piedras 00931-3346.

出版信息

Experientia. 1993 Feb 15;49(2):179-81. doi: 10.1007/BF01989427.

DOI:10.1007/BF01989427
PMID:8095027
Abstract

Two new cytotoxic antitumor diterpenoids of the cembrane class, named 14-deoxycrassin (3) and pseudoplexaurol (4), have been isolated from the Caribbean gorgonian octocoral Pseudoplexaura porosa. The structure of lactone 3, possessing the infrequently encountered alpha-methylene-delta-lactone ring, has been established from spectral and chemical data and that of alcohol 4 has been established from spectral data.

摘要

从加勒比海柳珊瑚多孔拟软柳珊瑚（Pseudoplexaura porosa）中分离出了两种新的细胞毒性抗肿瘤二萜类化合物，属于cembrane类，分别命名为14-脱氧粗珊瑚素（3）和假普雷克索醇（4）。内酯3具有罕见的α-亚甲基-δ-内酯环，其结构已通过光谱和化学数据确定，醇4的结构已通过光谱数据确定。

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