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保罗·谢尔研究所的200兆电子伏特质子治疗项目:概念设计与实际实现

The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization.

作者信息

Pedroni E, Bacher R, Blattmann H, Böhringer T, Coray A, Lomax A, Lin S, Munkel G, Scheib S, Schneider U

机构信息

Department of Radiation Medicine, Paul Scherrer Institute, Villigen PSI, Switzerland.

出版信息

Med Phys. 1995 Jan;22(1):37-53. doi: 10.1118/1.597522.

Abstract

The new proton therapy facility is being assembled at the Paul Scherrer Institute (PSI). The beam delivered by the PSI sector cyclotron can be split and brought into a new hall where it is degraded from 590 MeV down to an energy in the range of 85-270 MeV. A new beam line following the degrader is used to clean the low-energetic beam in phase space and momentum band. The analyzed beam is then injected into a compact isocentric gantry, where it is applied to the patient using a new dynamic treatment modality, the so-called spot-scanning technique. This technique will permit full three-dimensional conformation of the dose to the target volume to be realized in a routine way without the need for individualized patient hardware like collimators and compensators. By combining the scanning of the focused pencil beam within the beam optics of the gantry and by mounting the patient table eccentrically on the gantry, the diameter of the rotating structure has been reduced to only 4 m. In the article the degrees of freedom available on the gantry to apply the beam to the patient (with two rotations for head treatments) are also discussed. The devices for the positioning of the patient on the gantry (x rays and proton radiography) and outside the treatment room (the patient transporter system and the modified mechanics of the computer tomograph unit) are briefly presented. The status of the facility and first experimental results are introduced for later reference.

摘要

新的质子治疗设施正在保罗·谢勒研究所(PSI)组装。PSI扇形回旋加速器发出的束流可以被分割并引入一个新的大厅,在那里束流能量从590兆电子伏特降低到85 - 270兆电子伏特的范围。在降解器之后的一条新束流线用于在相空间和动量带中净化低能束流。然后,经过分析的束流被注入一个紧凑型等中心机架,在那里使用一种新的动态治疗方式——所谓的点扫描技术对患者进行治疗。这种技术将允许以常规方式实现对靶区剂量的全三维适形,而无需像准直器和补偿器这样的个体化患者硬件。通过在机架的束流光学系统内组合聚焦笔形束的扫描,并通过将患者床偏心安装在机架上,旋转结构的直径已减小到仅4米。在本文中,还讨论了在机架上用于将束流施加到患者身上的自由度(用于头部治疗有两个旋转角度)。简要介绍了用于在机架上(X射线和质子射线照相)以及治疗室外(患者运输系统和计算机断层扫描单元的改进机械装置)对患者进行定位的设备。介绍了该设施的现状和首批实验结果以供后续参考。

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