Von Feldt J M
Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Postgrad Med. 1995 Apr;97(4):79, 83, 86 passim.
Systemic lupus erythematosus (SLE) is a multisystem disease that predominantly affects women. Probable causative factors include genetic predisposition, complement deficiencies, persistence of antigen, drugs, and environmental factors. The widely varying presentations of SLE include skin, musculoskeletal, cardiovascular, renal, pulmonary, gastrointestinal, neuropsychiatric, systemic, hematologic, and immunologic manifestations. Milder symptoms can be managed with nonsteroidal anti-inflammatory drugs and antimalarial agents. Corticosteroids and cytotoxic drugs are given in more severe disease.
系统性红斑狼疮（SLE）是一种主要影响女性的多系统疾病。可能的致病因素包括遗传易感性、补体缺陷、抗原持续存在、药物和环境因素。SLE的表现形式广泛多样，包括皮肤、肌肉骨骼、心血管、肾脏、肺部、胃肠道、神经精神、全身、血液学和免疫学表现。较轻的症状可用非甾体抗炎药和抗疟药治疗。病情较重时则使用皮质类固醇和细胞毒性药物。
